Human RAB7B activation kit by CRISPRa

SKU GA117369

RAB7B CRISPRa kit - CRISPR gene activation of human RAB7B, member RAS oncogene family

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: RAB7B
• Locus ID: 338382
• Components:

  GA117369G1, RAB7B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA117369G2, RAB7B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA117369G3, RAB7B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001164522, NM_001304839, NM_177403
• UniProt ID: Q96AH8
• Synonyms: RAB7
• Summary: Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.[UniProtKB/Swiss-Prot Function]