Human CCDC46 (CEP112) activation kit by CRISPRa

SKU GA116374

CEP112 CRISPRa kit - CRISPR gene activation of human centrosomal protein 112

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: CEP112
• Locus ID: 201134
• Components:

  GA116374G1, CCDC46 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA116374G2, CCDC46 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA116374G3, CCDC46 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001037325, NM_001199165, NM_001302891, NM_145036, NR_126542, NM_001353127, NM_001353128, NM_001353129
• UniProt ID: Q8N8E3
• Synonyms: CCDC46; MACOCO
• Summary: This gene encodes a coiled-coil domain containing protein that belongs to the cell division control protein 42 effector protein family. In neurons, it localizes to the cytoplasm of dendrites and is also enriched in the nucleus where it interacts with the RNA polymerase III transcriptional repressor Maf1 to regulate gamma-aminobutyric acid A receptor surface expression. In addition, the protein has been identified as a component of the human centrosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]