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Human MLKL activation kit by CRISPRa

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SKU
GA116297
MLKL CRISPRa kit - CRISPR gene activation of human mixed lineage kinase domain like pseudokinase
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC213152 MLKL (Myc-DDK-tagged)-Human mixed lineage kinase domain-like (MLKL), transcript variant 1
10 ug
$289.00 $686.00

Other products for "MLKL"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol MLKL
Locus ID 197259
Components

GA116297G1, MLKL gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA116297G2, MLKL gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA116297G3, MLKL gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001142497, NM_152649
UniProt ID Q8NB16
Synonyms hMLKL
Summary This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. provided by RefSeq, Sep 2015
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Documents
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Other Versions
SKU Description Size Price
KN413152 MLKL - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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