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Human RNF145 activation kit by CRISPRa

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SKU
GA115878
RNF145 CRISPRa kit - CRISPR gene activation of human ring finger protein 145
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC216033 RNF145 (Myc-DDK-tagged)-Human ring finger protein 145 (RNF145), transcript variant 2
10 ug
$589.00 $633.00

Other products for "RNF145"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol RNF145
Locus ID 153830
Components

GA115878G1, RNF145 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA115878G2, RNF145 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA115878G3, RNF145 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001199380, NM_001199381, NM_001199382, NM_001199383, NM_144726
UniProt ID Q96MT1
Synonyms DKFZp686M11215; FLJ31951; FLJ44310
Summary E3 ubiquitin ligase that catalyzes the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. In response to bacterial infection, negatively regulates the phagocyte oxidative burst by controlling the turnover of the NADPH oxidase complex subunits. Promotes monoubiquitination of CYBA and 'Lys-48'-linked polyubiquitination and degradation of CYBB NADPH oxidase catalytic subunits, both essential for the generation of antimicrobial reactive oxygen species. Involved in the maintenance of cholesterol homeostasis. In response to high sterol concentrations ubiquitinates HMGCR, a rate-limiting enzyme in cholesterol biosynthesis, and targets it for degradation. The interaction with INSIG1 is required for this function. In addition, triggers ubiquitination of SCAP, likely inhibiting its transport to the Golgi apparatus and the subsequent processing/maturation of SREBPF2, ultimately downregulating cholesterol biosynthesis.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN416033 RNF145 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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