Human Repulsive Guidance Molecule C (HFE2) activation kit by CRISPRa

SKU GA115681

HJV CRISPRa kit - CRISPR gene activation of human hemojuvelin BMP co-receptor

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: HJV
• Locus ID: 148738
• Components:

  GA115681G1, Repulsive Guidance Molecule C gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA115681G2, Repulsive Guidance Molecule C gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA115681G3, Repulsive Guidance Molecule C gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001316767, NM_145277, NM_202004, NM_213652, NM_213653
• UniProt ID: Q6ZVN8
• Synonyms: HFE2A; HJV; JH; RGMC
• Summary: The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Oct 2015]