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Human HOGA1 activation kit by CRISPRa

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SKU
GA114371
HOGA1 CRISPRa kit - CRISPR gene activation of human 4-hydroxy-2-oxoglutarate aldolase 1
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC208461 HOGA1 (Myc-DDK-tagged)-Human 4-hydroxy-2-oxoglutarate aldolase 1 (HOGA1), nuclear gene encoding mitochondrial protein, transcript variant 1
10 ug
$300.00

Other products for "HOGA1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol HOGA1
Locus ID 112817
Components

GA114371G1, HOGA1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA114371G2, HOGA1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA114371G3, HOGA1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001134670, NM_138413
UniProt ID Q86XE5
Synonyms C10orf65; DHDPS2; DHDPSL; HP3; NPL2
Summary The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. provided by RefSeq, Nov 2010
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Documents
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Other Versions
SKU Description Size Price
KN408461 HOGA1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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