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Human DUOXA1 activation kit by CRISPRa

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SKU
GA114032
DUOXA1 CRISPRa kit - CRISPR gene activation of human dual oxidase maturation factor 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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100 ul
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RC206754 DUOXA1 (Myc-DDK-tagged)-Human dual oxidase maturation factor 1 (DUOXA1)
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Other products for "DUOXA1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol DUOXA1
Locus ID 90527
Components

GA114032G1, DUOXA1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA114032G2, DUOXA1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA114032G3, DUOXA1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001276264, NM_001276265, NM_001276266, NM_001276267, NM_001276268, NM_144565
UniProt ID Q1HG43
Synonyms mol; NIP; NUMBIP
Summary Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jan 2013
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Documents
Resources
Other Versions
SKU Description Size Price
KN406754 DUOXA1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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