Human LZTS2 activation kit by CRISPRa

SKU GA113550

LZTS2 CRISPRa kit - CRISPR gene activation of human leucine zipper tumor suppressor 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: LZTS2
• Locus ID: 84445
• Components:

  GA113550G1, LZTS2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA113550G2, LZTS2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA113550G3, LZTS2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001318099, NM_001318100, NM_001318101, NM_032429
• UniProt ID: Q9BRK4
• Synonyms: LAPSER1
• Summary: The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]