Human PTOP (ACD) activation kit by CRISPRa

SKU GA112225

ACD CRISPRa kit - CRISPR gene activation of human ACD shelterin complex subunit and telomerase recruitment factor

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ACD
• Locus ID: 65057
• Components:

  GA112225G1, PTOP gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA112225G2, PTOP gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA112225G3, PTOP gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001082486, NM_001082487, NM_022914
• UniProt ID: Q96AP0
• Synonyms: PIP1; PTOP; TINT1; TPP1
• Summary: This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq, Jul 2008]