Human TMPRSS3 activation kit by CRISPRa

SKU GA112106

TMPRSS3 CRISPRa kit - CRISPR gene activation of human transmembrane serine protease 3

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: TMPRSS3
• Locus ID: 64699
• Components:

  GA112106G1, TMPRSS3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA112106G2, TMPRSS3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA112106G3, TMPRSS3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001256317, NM_024022, NM_032401, NM_032404, NM_032405, NR_027348, NR_046020
• UniProt ID: P57727
• Synonyms: DFNB8; DFNB10; ECHOS1; TADG12
• Summary: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]