Human MCCC2 activation kit by CRISPRa

SKU GA111963

MCCC2 CRISPRa kit - CRISPR gene activation of human methylcrotonoyl-CoA carboxylase 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: MCCC2
• Locus ID: 64087
• Components:

  GA111963G1, MCCC2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA111963G2, MCCC2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA111963G3, MCCC2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_022132, NM_001363147
• UniProt ID: Q9HCC0
• Synonyms: MCCB
• Summary: This gene encodes the small subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]