Human HDAC8 activation kit by CRISPRa

SKU GA111031

HDAC8 CRISPRa kit - CRISPR gene activation of human histone deacetylase 8

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: HDAC8
• Locus ID: 55869
• Components:

  GA111031G1, HDAC8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA111031G2, HDAC8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA111031G3, HDAC8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001166418, NM_001166419, NM_001166420, NM_001166422, NM_001166448, NM_018486, NR_051952
• UniProt ID: Q9BY41
• Synonyms: CDA07; CDLS5; HD8; HDACL1; MRXS6; RPD3; WTS
• Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]