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Human ALS2CR2 (STRADB) activation kit by CRISPRa

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SKU
GA110753
STRADB CRISPRa kit - CRISPR gene activation of human STE20 related adaptor beta
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA324160 Anti-STRADB rabbit polyclonal antibody
100 ul
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RC203432 STRADB (Myc-DDK-tagged)-Human STE20-related kinase adaptor beta (STRADB), transcript variant 1
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Other products for "STRADB"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol STRADB
Locus ID 55437
Components

GA110753G1, ALS2CR2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA110753G2, ALS2CR2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA110753G3, ALS2CR2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001206864, NM_018571
UniProt ID Q9C0K7
Synonyms ALS2CR2; CALS-21; ILPIP; ILPIPA; PAPK; PRO1038
Summary This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, May 2011
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Documents
Resources
Other Versions
SKU Description Size Price
KN403432 STRADB - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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