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Human LAPTM4B activation kit by CRISPRa

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SKU
GA110731
LAPTM4B CRISPRa kit - CRISPR gene activation of human lysosomal protein transmembrane 4 beta
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA342374 Rabbit Polyclonal Anti-LAPTM4B Antibody
100 ul
$585.00
RC207325 LAPTM4B (Myc-DDK-tagged)-Human lysosomal protein transmembrane 4 beta (LAPTM4B)
10 ug
$300.00

Other products for "LAPTM4B"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol LAPTM4B
Locus ID 55353
Components

GA110731G1, LAPTM4B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA110731G2, LAPTM4B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA110731G3, LAPTM4B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_018407
UniProt ID Q86VI4
Synonyms LAPTM4beta; LC27
Summary Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN407325 LAPTM4B - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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