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Human PLEKHO1 activation kit by CRISPRa

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SKU
GA109628
PLEKHO1 CRISPRa kit - CRISPR gene activation of human pleckstrin homology domain containing O1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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100 ul
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RC203969 PLEKHO1 (Myc-DDK-tagged)-Human pleckstrin homology domain containing, family O member 1 (PLEKHO1)
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Other products for "PLEKHO1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol PLEKHO1
Locus ID 51177
Components

GA109628G1, PLEKHO1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA109628G2, PLEKHO1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA109628G3, PLEKHO1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001304722, NM_001304723, NM_001304724, NM_016274
UniProt ID Q53GL0
Synonyms CKIP-1; CKIP1; JBP; OC120
Summary Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN403969 PLEKHO1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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