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Human EMC9 activation kit by CRISPRa

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SKU
GA109500
EMC9 CRISPRa kit - CRISPR gene activation of human ER membrane protein complex subunit 9
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA360736 EMC9 Antibody - C-terminal region
100 ul
$585.00
RC200034 EMC9 (Myc-DDK-tagged)-Human family with sequence similarity 158, member A (FAM158A)
10 ug
$300.00

Other products for "EMC9"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol EMC9
Locus ID 51016
Components

GA109500G1, EMC9 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA109500G2, EMC9 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA109500G3, EMC9 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_016049, NM_001346874, NM_001346875, NM_001346876, NM_001346877
UniProt ID Q9Y3B6
Synonyms C14orf122; CGI-112; FAM158A
Summary Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:30415835, PubMed:29809151, PubMed:29242231, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:30415835, PubMed:29809151, PubMed:29242231). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:30415835, PubMed:29809151). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29809151, PubMed:29242231). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN400034 EMC9 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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