Human RBFOX2 activation kit by CRISPRa

SKU GA108383

RBFOX2 CRISPRa kit - CRISPR gene activation of human RNA binding fox-1 homolog 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: RBFOX2
• Locus ID: 23543
• Components:

  GA108383G1, RBFOX2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA108383G2, RBFOX2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA108383G3, RBFOX2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001031695, NM_001082576, NM_001082577, NM_001082578, NM_001082579, NM_014309, NM_001349982, NM_001349983, NM_001349989, NM_001349990, NM_001349991, NM_001349992, NM_001349994, NM_001349995, NM_001349996, NM_001349997, NM_001349998, NM_001349999
• UniProt ID: O43251
• Synonyms: dJ106I20.3; Fox-2; FOX2; fxh; HNRBP2; HRNBP2; RBM9; RTA
• Summary: This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]