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Human PLEKHM2 activation kit by CRISPRa

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SKU
GA108124
PLEKHM2 CRISPRa kit - CRISPR gene activation of human pleckstrin homology and RUN domain containing M2
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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100 ug
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RC220299 PLEKHM2 (Myc-DDK-tagged)-Human pleckstrin homology domain containing, family M (with RUN domain) member 2 (PLEKHM2)
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Other products for "PLEKHM2"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol PLEKHM2
Locus ID 23207
Components

GA108124G1, PLEKHM2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA108124G2, PLEKHM2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA108124G3, PLEKHM2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_015164
UniProt ID Q8IWE5
Synonyms SKIP
Summary This gene encodes a protein that binds the plus-end directed microtubule motor protein kinesin, together with the lysosomal GTPase Arl8, and is required for lysosomes to distribute away from the microtubule-organizing center. The encoded protein belongs to the multisubunit BLOC-one-related complex that regulates lysosome positioning. It binds a Salmonella effector protein called Salmonella induced filament A and is a critical host determinant in Salmonella pathogenesis. It has a domain architecture consisting of an N-terminal RPIP8, UNC-14, and NESCA (RUN) domain that binds kinesin-1 as well as the lysosomal GTPase Arl8, and a C-terminal pleckstrin homology domain that binds the Salmonella induced filament A effector protein. Naturally occurring mutations in this gene lead to abnormal localization of lysosomes, impaired autophagy flux and are associated with recessive dilated cardiomyopathy and left ventricular noncompaction. provided by RefSeq, Feb 2017
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Documents
Resources
Other Versions
SKU Description Size Price
KN420299 PLEKHM2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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