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Human PEG10 activation kit by CRISPRa

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SKU
GA108028
PEG10 CRISPRa kit - CRISPR gene activation of human paternally expressed 10
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA809524 PEG10 mouse monoclonal antibody,clone OTI1G10 100 ul
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RC208683 PEG10 (Myc-DDK-tagged)-Human paternally expressed 10 (PEG10), transcript variant 1
10 ug
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Other products for "PEG10"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol PEG10
Locus ID 23089
Components

GA108028G1, PEG10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA108028G2, PEG10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA108028G3, PEG10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001040152, NM_001172437, NM_001172438, NM_001184961, NM_001184962, NM_015068
UniProt ID Q86TG7
Synonyms EDR; HB-1; Mar2; Mart2; MEF3L; RGAG3
Summary This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. provided by RefSeq, Oct 2014
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Other Versions
SKU Description Size Price
KN408683 PEG10 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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