Human RIP3 (RIPK3) activation kit by CRISPRa

SKU GA107582

RIPK3 CRISPRa kit - CRISPR gene activation of human receptor interacting serine/threonine kinase 3

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: RIPK3
• Locus ID: 11035
• Components:

  GA107582G1, RIP3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA107582G2, RIP3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA107582G3, RIP3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_006871
• UniProt ID: Q9Y572
• Synonyms: RIP3
• Summary: The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor. [provided by RefSeq, Jul 2008]