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Human spindlin 1 (SPIN1) activation kit by CRISPRa

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SKU
GA107494
SPIN1 CRISPRa kit - CRISPR gene activation of human spindlin 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA364558 SPIN1 rabbit polyclonal antibody
100 ul
$310.00
RC201938 SPIN1 (Myc-DDK-tagged)-Human spindlin 1 (SPIN1)
10 ug
$300.00

Other products for "SPIN1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol SPIN1
Locus ID 10927
Components

GA107494G1, spindlin 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA107494G2, spindlin 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA107494G3, spindlin 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_006717
UniProt ID Q9Y657
Synonyms SPIN; TDRD24
Summary Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN401938 SPIN1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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