Human REC8 activation kit by CRISPRa

SKU GA106758

REC8 CRISPRa kit - CRISPR gene activation of human REC8 meiotic recombination protein

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: REC8
• Locus ID: 9985
• Components:

  GA106758G1, REC8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106758G2, REC8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106758G3, REC8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001048205, NM_005132
• UniProt ID: O95072
• Synonyms: HR21spB; REC8L1; Rec8p
• Summary: This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]