Human GDF15 activation kit by CRISPRa

SKU GA106364

GDF15 CRISPRa kit - CRISPR gene activation of human growth differentiation factor 15

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: GDF15
• Locus ID: 9518
• Components:

  GA106364G1, GDF15 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106364G2, GDF15 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106364G3, GDF15 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_004864
• UniProt ID: Q99988
• Synonyms: GDF-15; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB
• Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016]