Human HAND2 activation kit by CRISPRa

SKU GA106321

HAND2 CRISPRa kit - CRISPR gene activation of human heart and neural crest derivatives expressed 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: HAND2
• Locus ID: 9464
• Components:

  GA106321G1, HAND2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA106321G2, HAND2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA106321G3, HAND2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_021973
• UniProt ID: P61296
• Synonyms: bHLHa26; dHand; DHAND2; Hed; Thing2
• Summary: The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul 2008]