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Human BCL10 activation kit by CRISPRa

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SKU
GA105943
BCL10 CRISPRa kit - CRISPR gene activation of human BCL10 immune signaling adaptor
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

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Other products for "BCL10"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol BCL10
Locus ID 8915
Components

GA105943G1, BCL10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA105943G2, BCL10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA105943G3, BCL10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_003921, NM_001320715
UniProt ID O95999
Synonyms c-E10; CARMEN; CIPER; CLAP; IMD37; mE10
Summary This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. provided by RefSeq, Mar 2016
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Documents
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Other Versions
SKU Description Size Price
KN408752 BCL10 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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