Human CGGBP1 activation kit by CRISPRa

SKU GA105659

CGGBP1 CRISPRa kit - CRISPR gene activation of human CGG triplet repeat binding protein 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: CGGBP1
• Locus ID: 8545
• Components:

  GA105659G1, CGGBP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105659G2, CGGBP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105659G3, CGGBP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001008390, NM_001195308, NM_003663
• UniProt ID: Q9UFW8
• Synonyms: CGGBP; p20-CGGBP
• Summary: This gene encodes a CGG repeat-binding protein that primarily localizes to the nucleus. CGG trinucleotide repeats are implicated in many disorders as they often act as transcription- and translation-regulatory elements, can produce hairpin structures which cause DNA replication errors, and form regions prone to chromosomal breakage. CGG repeats are also targets for CpG methylation. In addition to its ability to bind CGG repeats and regulate transcription, this gene is believed to play a role in DNA damage repair and telomere protection. In vitro studies indicate this protein does not bind to methylated CpG sequences. [provided by RefSeq, Jul 2017]