Human RAB7 (RAB7A) activation kit by CRISPRa

SKU GA105347

RAB7A CRISPRa kit - CRISPR gene activation of human RAB7A, member RAS oncogene family

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: RAB7A
• Locus ID: 7879
• Components:

  GA105347G1, RAB7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105347G2, RAB7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105347G3, RAB7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_004637
• UniProt ID: P51149
• Synonyms: PRO2706; RAB7
• Summary: RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]