RAB7 (RAB7A) (NM_004637) Human Tagged ORF Clone
$450.00
In Stock*
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
|---|---|
| Target Symbol | RAB7 |
| Synonyms | CMT2B; PRO2706; RAB7 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Chromatograms |
Chromatograms
 Sequencher program is needed, download here |
| Restriction Sites |
SgfI-MluI Cloning Scheme for this gene
|
Plasmid Map
|
| ACCN | NM_004637 |
| ORF Size | 621 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_004637.6 |
| RefSeq Size | 2240 bp |
| RefSeq ORF | 624 bp |
| Locus ID | 7879 |
| UniProt ID | P51149 |
| Cytogenetics | 3q21.3 |
| Protein Families | Druggable Genome |
| MW | 23.5 kDa |
| Summary | RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. provided by RefSeq, Jul 2008 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_004637" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC201776L1 | Lenti ORF clone of Human RAB7A, member RAS oncogene family (RAB7A), Myc-DDK-tagged | 10 ug |
$750.00
|
|
| RC201776L2 | Lenti ORF clone of Human RAB7A, member RAS oncogene family (RAB7A), mGFP tagged | 10 ug |
$750.00
|
|
| RC201776L3 | Lenti ORF clone of Human RAB7A, member RAS oncogene family (RAB7A), Myc-DDK-tagged | 10 ug |
$750.00
|
|
| RC201776L4 | Lenti ORF clone of Human RAB7A, member RAS oncogene family (RAB7A), mGFP tagged | 10 ug |
$750.00
|
|
| RG201776 | RAB7A (tGFP-tagged) - Human RAB7A, member RAS oncogene family (RAB7A) | 10 ug |
$489.00
$650.00
|
|
| SC117240 | RAB7A (untagged)-Human RAB7A, member RAS oncogene family (RAB7A) | 10 ug |
$450.00
|
|
Citations
Extracellular Vesicle-Delivered tRF-His-GTG-1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID-19
Liao, Liu, Chen et al
Adv Sci (Weinh) (2026)
Liao, Liu, Chen et al
Adv Sci (Weinh) (2026)
Cited by 4
LRRK2 mutations impair depolarization-induced mitophagy through inhibition of mitochondrial accumulation of RAB10
Wauters, Cornelissen, Imberechts et al
Autophagy (2019) 16 (2), 203-222 DOI: 10.1080/15548627.2019.1603548
Wauters, Cornelissen, Imberechts et al
Autophagy (2019) 16 (2), 203-222 DOI: 10.1080/15548627.2019.1603548
AI Summary: OriGene contributed to this study by providing pCMV6-Entry and pCMV6-XL5 vectors containing cDNAs for various human RAB proteins—including FLAG-tagged RAB3A, RAB5B, RAB7A, RAB10, RAB12, RAB29 (RC203973, RC208529, RC201776, RC201464, RC211472, RC200431), and untagged RAB10 (SC114472)—which were used to investigate the role of RAB10 in LRRK2 mutation-induced mitophagy impairment.
Modulation of insulin signalling and calcium homeostasis by endosomes in pancreatic beta-cells
Albrecht
Thesis (2015)
Albrecht
Thesis (2015)
Snippet: … To generate TagBFP-Rab5a, human Rab5a cDNA was PCR amplified from pCMV6-Entry-Rab5A (Origene, Rockville, MD) using primers #15,#16 and inserted into pTagBFP-C using SacI and BamHI restriction sites. To generate TagBFP-Rab7, human Rab7 cDNA was PCR amplified from pCMV6-Entry-Rab7 (Origene) using primers #17,#18 and inserted into pTagBFP-C using SacI and BamHI restriction sites. …
Showing 1-3 of 3 papers.
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