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Human XBP1 activation kit by CRISPRa

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SKU
GA105164
XBP1 CRISPRa kit - CRISPR gene activation of human X-box binding protein 1
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC201959 XBP1 (Myc-DDK-tagged)-Human X-box binding protein 1 (XBP1), transcript variant 1
10 ug
$450.00

Other products for "XBP1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol XBP1
Locus ID 7494
Components

GA105164G1, XBP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA105164G2, XBP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA105164G3, XBP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001079539, NM_005080
UniProt ID P17861
Synonyms TREB-5; TREB5; XBP-1; XBP2
Summary This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN201959 XBP1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201959BN XBP1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201959LP XBP1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201959RB XBP1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN401959 XBP1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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