Human TRPM2 activation kit by CRISPRa

SKU GA104983

TRPM2 CRISPRa kit - CRISPR gene activation of human transient receptor potential cation channel subfamily M member 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: TRPM2
• Locus ID: 7226
• Components:

  GA104983G1, TRPM2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104983G2, TRPM2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104983G3, TRPM2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001001188, NM_003307, NR_038257, NM_001320350, NM_001320351, NM_001320352
• UniProt ID: O94759
• Synonyms: EREG1; KNP3; LTRPC2; MGC133383; NUDT9H; NUDT9L1; TRPC7
• Summary: The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]