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Human TPMT activation kit by CRISPRa

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SKU
GA104956
TPMT CRISPRa kit - CRISPR gene activation of human thiopurine S-methyltransferase
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA500966 Anti-TPMT mouse monoclonal antibody, clone OTI2A2 (formerly 2A2) 100 ul
$447.00
RC203309 TPMT (Myc-DDK-tagged)-Human thiopurine S-methyltransferase (TPMT)
10 ug
$300.00

Other products for "TPMT"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol TPMT
Locus ID 7172
Components

GA104956G1, TPMT gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA104956G2, TPMT gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA104956G3, TPMT gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_000367, NM_001346817, NM_001346818
UniProt ID P51580
Synonyms OTTHUMP00000016076; S-adenosyl-L-methionine:thiopurine S-methyltransferase; thiopurine methyltransferase; thiopurine S-methyltransferase
Summary This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. provided by RefSeq, Aug 2014
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Other Versions
SKU Description Size Price
KN403309 TPMT - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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