Human TRF2 (TERF2) activation kit by CRISPRa

SKU GA104824

TERF2 CRISPRa kit - CRISPR gene activation of human telomeric repeat binding factor 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: TERF2
• Locus ID: 7014
• Components:

  GA104824G1, TRF2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104824G2, TRF2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104824G3, TRF2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_005652
• UniProt ID: Q15554
• Synonyms: TRBF2; TRF2
• Summary: This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008]