Human DYNLT1 activation kit by CRISPRa

SKU GA104809

DYNLT1 CRISPRa kit - CRISPR gene activation of human dynein light chain Tctex-type 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: DYNLT1
• Locus ID: 6993
• Components:

  GA104809G1, DYNLT1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104809G2, DYNLT1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104809G3, DYNLT1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001291602, NM_001291603, NM_006519
• UniProt ID: P63172
• Synonyms: CW-1; TCTEL1; tctex-1
• Summary: This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]