Human SIAH1 activation kit by CRISPRa

SKU GA104408

SIAH1 CRISPRa kit - CRISPR gene activation of human siah E3 ubiquitin protein ligase 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: SIAH1
• Locus ID: 6477
• Components:

  GA104408G1, SIAH1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA104408G2, SIAH1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA104408G3, SIAH1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001006610, NM_001006611, NM_003031
• UniProt ID: Q8IUQ4
• Synonyms: SIAH1A
• Summary: This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]