Human PMS2 activation kit by CRISPRa

SKU GA103634

PMS2 CRISPRa kit - CRISPR gene activation of human PMS1 homolog 2, mismatch repair system component

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PMS2
• Locus ID: 5395
• Components:

  GA103634G1, PMS2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103634G2, PMS2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103634G3, PMS2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000535, NM_001018040, NR_003085, NM_001322003, NM_001322004, NM_001322005, NM_001322006, NM_001322007, NM_001322008, NM_001322009, NM_001322010, NM_001322011, NM_001322012, NM_001322013, NM_001322014, NM_001322015, NR_136154
• UniProt ID: P54278
• Synonyms: HNPCC4; PMS2CL; PMSL2
• Summary: The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016]