Human PCCB activation kit by CRISPRa

SKU GA103407

PCCB CRISPRa kit - CRISPR gene activation of human propionyl-CoA carboxylase subunit beta

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PCCB
• Locus ID: 5096
• Components:

  GA103407G1, PCCB gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103407G2, PCCB gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103407G3, PCCB gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000532, NM_001178014
• UniProt ID: P05166
• Synonyms: DKFZp451E113
• Summary: The protein encoded by this gene is a subunit of the propionyl-CoA carboxylase (PCC) enzyme, which is involved in the catabolism of propionyl-CoA. PCC is a mitochondrial enzyme that probably acts as a dodecamer of six alpha subunits and six beta subunits. This gene encodes the beta subunit of PCC. Defects in this gene are a cause of propionic acidemia type II (PA-2). Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]