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PCCB Rabbit Polyclonal Antibody

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SKU
TA308402
Rabbit polyclonal antibody to PCCase beta (propionyl Coenzyme A carboxylase, beta polypeptide)
Size:
100 ul
Conjugation:
Unconjugated
  $665.00
2 Weeks*
Bulk/Customize

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Specifications
Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity Bovine), Human (Predicted: Mouse, Pig, Rat, Xenopus, Zebrafish
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant fragment corresponding to a region within amino acids 167 and 480 of PCCB (Uniprot ID#P05166)
Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration lot specific
Purification Purified by antigen-affinity chromatography.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 58 kDa
Gene Name propionyl-CoA carboxylase beta subunit
Database Link
Background The protein encoded by this gene is a subunit of the propionyl-CoA carboxylase (PCC) enzyme, which is involved in the catabolism of propionyl-CoA. PCC is a mitochondrial enzyme that probably acts as a dodecamer of six alpha subunits and six beta subunits. This gene encodes the beta subunit of PCC. Defects in this gene are a cause of propionic acidemia type II (PA-2). provided by RefSeq
Synonyms DKFZp451E113
Note Seq homology of immunogen across species: Mouse (92%), Pig (94%), Rat (91%), Xenopus laevis (90%), Zebrafish (90%), Bovine (97%)
Reference Data
Protein Categories Enzyme: Ligase, Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways leucine and isoleucine degradation, Metabolic pathways, Propanoate metabolism, Valine
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Documents
Resources

file-alt Citations

Biochemical and anaplerotic applications of in vitro models of propionic acidemia and methylmalonic acidemia using patient-derived primary hepatocytes
Collado, Armstrong, Olson et al
Mol. Genet. Metab. (2020) 130 (3), 183-196 DOI: 10.1016/j.ymgme.2020.05.003
Cited by 34
AI Summary: In this study, OriGene’s PCCB primary antibody was used for immunoblotting to assess protein levels in patient-derived hepatocytes, helping to characterize disease-specific biochemical defects in propionic acidemia and methylmalonic acidemia models.
Snippet: Blots were probed overnight with primary antibody and 30 min at room temperature with secondary antibody in blocking buffer (LI-COR 927-40000). Primary antibodies (1:1000) include: PCCA (Bethyl Laboratories), PCCB (Origene), MMUT (ThermoFisher) and GAPDH
WB
Recapitulation of metabolic defects in a model of propionic acidemia using patient-derived primary hepatocytes
Chapman, Collado, Figler et al
Molecular Genetics and Metabolism (2015)
AI Summary: OriGene's PCCB antibody was used in this study to detect the PCCB protein by Western blotting, helping to analyze metabolic defects in patient-derived hepatocytes modeling propionic acidemia.
Snippet: Blots were probed overnight with primary antibody and 30 min at room temperature with secondary antibody in blocking buffer (LI-COR 927-40000). Primary antibodies (1:1000) include: βactin (Sigma A1978), PCCA (Bethyl Laboratories), and PCCB (Origene). ... Cite SaveSaving
WB
Showing 1-2 of 2 papers.
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