Human PAH activation kit by CRISPRa

SKU GA103375

PAH CRISPRa kit - CRISPR gene activation of human phenylalanine hydroxylase

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: PAH
• Locus ID: 5053
• Components:

  GA103375G1, PAH gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103375G2, PAH gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103375G3, PAH gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000277, NM_001354304
• UniProt ID: P00439
• Synonyms: PH; PKU; PKU1
• Summary: This gene encodes a member of the biopterin-dependent aromatic amino acid hydroxylase protein family. The encoded phenylalanine hydroxylase enzyme hydroxylates phenylalanine to tyrosine and is the rate-limiting step in phenylalanine catabolism. Deficiency of this enzyme activity results in the autosomal recessive disorder phenylketonuria. [provided by RefSeq, Aug 2017]