Human ODF2 activation kit by CRISPRa

SKU GA103310

ODF2 CRISPRa kit - CRISPR gene activation of human outer dense fiber of sperm tails 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ODF2
• Locus ID: 4957
• Components:

  GA103310G1, ODF2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA103310G2, ODF2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA103310G3, ODF2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001242352, NM_001242353, NM_001242354, NM_002540, NM_153432, NM_153433, NM_153435, NM_153436, NM_153437, NM_153439, NM_153440, NR_036754, NR_036755, NR_036756, NR_036757, NM_001351577, NM_001351578, NM_001351579, NM_001351580, NM_001351581, NM_001351582, NM_001351583, NM_001351584, NM_001351585, NM_001351586, NM_001351587, NM_001351588
• UniProt ID: Q5BJF6
• Synonyms: CT134; ODF2/1; ODF2/2; ODF84
• Summary: The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]