Human CD10 (MME) activation kit by CRISPRa

SKU GA102932

MME CRISPRa kit - CRISPR gene activation of human membrane metalloendopeptidase

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: MME
• Locus ID: 4311
• Components:

  GA102932G1, CD10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102932G2, CD10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102932G3, CD10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000902, NM_007287, NM_007288, NM_007289, NM_001354642, NM_001354643, NM_001354644
• UniProt ID: P08473
• Synonyms: CALLA; CD10; CMT2T; NEP; SCA43; SFE
• Summary: The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]