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CD10 (MME) Mouse Monoclonal Antibody [Clone ID: OTI3D11]

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SKU
TA504507
MME (CD10) mouse monoclonal antibody, clone OTI3D11 (formerly 3D11)
Size:
100 ul 30 ul
Formulation:
Standard Carrier-free
Conjugation:
Unconjugated Biotin HRP
  $447.00
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View other "CD10 or NM_007287" antibodies

Specifications
Specifications
Product Data
Clone Name OTI3D11
Application FC, WB
Recommended Dilution WB 1:2000, IHC 1:150
Reactivity Human, Mouse, Rat
Antibody Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Full length human recombinant protein of human MME(NP_009218) produced in HEK293T cell.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 85.3 kDa
Gene Name membrane metalloendopeptidase
Database Link
Background This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including GCG, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. provided by RefSeq
Synonyms CALLA; CD10; CMT2T; NEP; SCA43; SFE
Reference Data
Protein Categories CD Markers, Cytokines, Enzyme: Peptidases, Intracellular Proteins, Membrane Proteins, Nervous system: Neurodegenerative diseases
Protein Families Druggable Genome, Protease, Transmembrane
Protein Pathways Alzheimer's disease, Hematopoietic cell lineage, Renin-angiotensin system
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Other "OTI3D11" antibodies (4)
SKU Description Size Price
CF504507 Carrier-free (BSA/glycerol-free) MME mouse monoclonal antibody, clone OTI3D11 (formerly 3D11) 100 ug
$620.00
TA504507AM MME mouse monoclonal antibody,clone 3D11, Biotinylated 100 ul
$509.00
TA504507BM MME mouse monoclonal antibody,clone 3D11, HRP conjugated 100 ul
$509.00
TA504507S MME (CD10) mouse monoclonal antibody, clone OTI3D11 (formerly 3D11) 30 ul
$200.00

file-alt Citations

Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CAH1047R accompanied with pro-tumorigenic secretome
Liu, Liu, Xu et al
Int. J. Cancer (2019)
AI Summary: OriGene’s MME antibody was used in this study to detect membrane metallo-endopeptidase, helping to elucidate its role as a downstream effector of PI3K in mediating cellular senescence induced by oncogenic PIK3CAH1047R.
Snippet: AKT, phospho-PRAS40 (Thr246), PRAS40, p70 S6 Kinase (p70S6K), phospho-p70S6K (Thr389), RB, HA-tag, p21 (Cell Signaling Technology, Danvers, MA, USA), MME (OriGene Technologies, MA, USA), p53 (Bioworld Technology, This article is protected
WB
Showing 1-1 of 1 papers.
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