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Human MLH1 activation kit by CRISPRa

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SKU
GA102918
MLH1 CRISPRa kit - CRISPR gene activation of human mutL homolog 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA810261 MLH1 mouse monoclonal antibody,clone OTI3C1 100 ul
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RC201607 MLH1 (Myc-DDK-tagged)-Human mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) (MLH1), transcript variant 1
10 ug
$692.00

Other products for "MLH1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol MLH1
Locus ID 4292
Components

GA102918G1, MLH1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102918G2, MLH1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102918G3, MLH1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_000249, NM_001167617, NM_001167618, NM_001167619, NM_001258271, NM_001258273, NM_001258274, NM_001354615, NM_001354616, NM_001354617, NM_001354618, NM_001354619, NM_001354620, NM_001354621, NM_001354622, NM_001354623, NM_001354624, NM_001354625, NM_001354626, NM_001354627, NM_001354628, NM_001354629, NM_001354630
UniProt ID P40692
Synonyms COCA2; FCC2; hMLH1; HNPCC; HNPCC2
Summary The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). provided by RefSeq, Aug 2017
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Documents
Resources
Other Versions
SKU Description Size Price
KN201607 MLH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201607BN MLH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201607LP MLH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN201607RB MLH1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN401607 MLH1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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