Human Tau (MAPT) activation kit by CRISPRa

SKU GA102816

MAPT CRISPRa kit - CRISPR gene activation of human microtubule associated protein tau

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: MAPT
• Locus ID: 4137
• Components:

  GA102816G1, Tau gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102816G2, Tau gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102816G3, Tau gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001123066, NM_001123067, NM_001203251, NM_001203252, NM_005910, NM_016834, NM_016835, NM_016841, NM_173727
• UniProt ID: P10636
• Synonyms: DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU
• Summary: This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]