Human LTBP1 activation kit by CRISPRa

SKU GA102746

LTBP1 CRISPRa kit - CRISPR gene activation of human latent transforming growth factor beta binding protein 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: LTBP1
• Locus ID: 4052
• Components:

  GA102746G1, LTBP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102746G2, LTBP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102746G3, LTBP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000627, NM_001166264, NM_001166265, NM_001166266, NM_206943
• UniProt ID: Q14766
• Synonyms: MGC163161
• Summary: The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]