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Human KIR2DL4 activation kit by CRISPRa

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SKU
GA102576
KIR2DL4 CRISPRa kit - CRISPR gene activation of human killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA346319 Rabbit Polyclonal Anti-KIR2DL4 Antibody
100 ul
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RC214354L3V Lenti ORF particles, KIR2DL4 (Myc-DDK tagged) - Human killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (KIR2DL4), transcript variant 1, 200ul, >10^7 TU/mL
200 ul
$1,007.00

Other products for "KIR2DL4"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol KIR2DL4
Locus ID 3805
Components

GA102576G1, KIR2DL4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102576G2, KIR2DL4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102576G3, KIR2DL4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001080770, NM_001080772, NM_002255
UniProt ID Q99706
Synonyms CD158D; G9P; KIR-103AS; KIR103; KIR103AS
Summary Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly. provided by RefSeq, Jul 2016
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Documents
Resources
Other Versions
SKU Description Size Price
KN408307 KIR2DL4 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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