Human Integrin alpha 4 (ITGA4) activation kit by CRISPRa

SKU GA102467

ITGA4 CRISPRa kit - CRISPR gene activation of human integrin subunit alpha 4

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: ITGA4
• Locus ID: 3676
• Components:

  GA102467G1, Integrin alpha 4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102467G2, Integrin alpha 4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102467G3, Integrin alpha 4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000885, NM_001316312
• UniProt ID: P13612
• Synonyms: CD49D; IA4
• Summary: The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]