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Human INSIG1 activation kit by CRISPRa

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SKU
GA102439
INSIG1 CRISPRa kit - CRISPR gene activation of human insulin induced gene 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA345657 Rabbit Polyclonal Anti-INSIG1 Antibody
100 ul
$585.00
RC200312 INSIG1 (Myc-DDK-tagged)-Human insulin induced gene 1 (INSIG1), transcript variant 1
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$300.00

Other products for "INSIG1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol INSIG1
Locus ID 3638
Components

GA102439G1, INSIG1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA102439G2, INSIG1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA102439G3, INSIG1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_005542, NM_198336, NM_198337, NM_001346590, NM_001346591, NM_001346592, NM_001346593, NM_001346594
UniProt ID O15503
Synonyms CL-6; CL6
Summary This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants. provided by RefSeq, Oct 2016
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Documents
Resources
Other Versions
SKU Description Size Price
KN400312 INSIG1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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