Human IMPDH2 activation kit by CRISPRa

SKU GA102421

IMPDH2 CRISPRa kit - CRISPR gene activation of human inosine monophosphate dehydrogenase 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: IMPDH2
• Locus ID: 3615
• Components:

  GA102421G1, IMPDH2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102421G2, IMPDH2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102421G3, IMPDH2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000884
• UniProt ID: P12268
• Synonyms: IMPD2; IMPDH-II
• Summary: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]