Human HDAC1 activation kit by CRISPRa

SKU GA102088

HDAC1 CRISPRa kit - CRISPR gene activation of human histone deacetylase 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: HDAC1
• Locus ID: 3065
• Components:

  GA102088G1, HDAC1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102088G2, HDAC1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102088G3, HDAC1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_004964
• UniProt ID: Q13547
• Synonyms: GON-10; HD1; RPD3; RPD3L1
• Summary: Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. [provided by RefSeq, Jul 2008]