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Human FEN1 activation kit by CRISPRa

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SKU
GA101562
FEN1 CRISPRa kit - CRISPR gene activation of human flap structure-specific endonuclease 1
  $1,657.00
4 Weeks*

Frequently Bought Together (2)

TA802762 FEN1 mouse monoclonal antibody, clone OTI1F3 (formerly 1F3) 100 ul
$447.00
RC201785 FEN1 (Myc-DDK-tagged)-Human flap structure-specific endonuclease 1 (FEN1)
10 ug
$686.00

Other products for "FEN1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol FEN1
Locus ID 2237
Components

GA101562G1, FEN1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA101562G2, FEN1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA101562G3, FEN1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_004111
UniProt ID P39748
Synonyms FEN-1; MF1; RAD2
Summary The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN401785 FEN1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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